Biochemistry 2280A Lecture Notes - Lecture 26: Basal Lamina, Adenoma, Adenocarcinoma
25 Mar 2017
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Document Summary
The leading cause of death in north america. Becoming more prevalent as the population ages. Cancer is characterized by genetic and biochemical defects. Biochemistry and molecular biology provide avenues for cutes. Not a problem as can be removed surgically: adenocarcinoma (malignant, not contained, cells also more abnormal. Malignant tumors not contained thus prone to mestastis (metastasize) that is spread from their primary site to one or more secondary sites. Different cancers spread to different sites: common sites: bones, liver, lungs. Have a basal lamina containing the tumor in the epithelium. But the tumor breaks through basal lamina. Travels through the blood stream (only one out of 1000 cells do this but it causes problems) Adhere to the blood vessel wall in liver. Proliferate to form metasis in the liver now. Forms of breast, prostate ovarian and intestinal cancers. Avoid dna damaging agents: radiation (x rays, uv, mutagens.
