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Lecture 7

Biochemistry 2280A Lecture 7: 7 - Lipids and Biological Membranes

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Biochemistry 2280A
Eric Ball

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Wednesday, September 30, 2015 Lipids and Biological Membranes McLachlin Topic 7 — Lecture 9 Learning Objectives - describe and distinguish between different classes of lipids - describe the biological role of the different classes of lipids - explain the properties of lipid bilayers, and why certain lipids form bilayers - predict the effect of changes in composition of a lipid bilayer on its fluidity Four Main Classes of Biomolecules Types of Lipids — Fatty Acids - used for energy and structure Fatty Acid Saturation and Blood Cholesterol - LDL = low-density lipoprotein, carries cholesterol to tissues - HDL = high-density lipoprotein, scavenges cholesterol from tissues 1 Wednesday, September 30, 2015 Types of Lipids — Triacylglycerols - energy storage molecules Types of Lipids — Glycerophospholipids - used in membranes Types of Lipids — Sphingolipids - used in membranes Types of Lipids — Steroids - hormones (cholesterol — membranes) - cyclopentanoperhydrophenanthrene ring system Types of Lipids — Other 2 Wednesday, September 30, 2015 Amphipathic Lipids - polar head group and non-polar tail - not very soluble in water - hydrophilic heads - when we put a bunch of these in an aqueous solution, they will cluster together… Amphipathic Lipids Associate in a Bilayer - coated/protected by hydrophilic head group - liposome - protect hydrophobic regions Lipids can Diffuse Within the Bilayer - diffusion rate determined by: temperature • • length of chains • degree of unsaturation • cholesterol concentration - can move around — wiggle, rotate, etc. - hydrophilic part doesn't want to go into a hydrophobia region - this means they don't flip flop very often - rate of diffusion does impact fluidity of bilayer - less fluid means they'
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