Biochemistry 2280A Lecture Notes - Lecture 5: Enzyme Kinetics, Mucus, Innate Immune System
23 Apr 2017
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Describe the catalytic mechanism of the enzyme, lysozyme. Be able to use the michaelis-menten equation to describe enzyme kinetics. Describe the mechanism of action of competitive inhibitors of enzymes. Hydrolyzes a polysaccharide found in cell walls of some bacteria. An evolutionary older defence strategy found in plants, insects, fungi, etc. 1909: laschtschenko discovered anti bacterial properties of egg white. 1922: after wwi, alexander fleming (biologist and pharmacologist) observed anti bacterial properties of nasal mucus from a patient with a head cold ; the term lysozyme was created and is the name of the enzyme involved in destructing bacterial cell walls. ** rst enzyme for which detailed mechanism of catalysis was determined. Transition state stabilization: decreases activation energy needed. Study of how rate of the reaction is in uenced by substrate concentration, inhibitors, etc: can help discover how an enzyme works. Rate of reaction will depend on various factors, etc: af nity of enzyme for substrate, substrate concentration.
