Biochemistry 2280A Lecture Notes - Lecture 21: Metachromatic Leukodystrophy, Classical Genetics, Animal Husbandry

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The techniques which recombine dna fragments from different sources into new molecules with unique features. Engineering of biological systems with the goal of carryon out novel functions or performing existing functions more efficiently. Been doing it for 100s of years through classical genetic selection. Plan/crop and livestock breeding are examples of humans manipulation genetic material. Slow: limited by the breeding time of the organism and chance of genetic events. Exchange of genetic materials is limited to breeding species. Rapid acts in a few days, no limitations. Significance of recombinant dna technology: research key tool to understand cell and molecular structure/function, biotechnology major impact on society. Medicine drug production and design, insulin ,hgj, vaccines, artemisinin (malaria), interleukins. Diagnosis of disease detect pathogens and disease causing genes through their dna signatures. Genetic counseling does an individual carry a disease causing gene. We can add back functional genes to cure disease (crispr-cas9)

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