Biochemistry 2280A Lecture Notes - Lecture 1: Contig, Cisplatin, Nitrocellulose
8 Feb 2018
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Document Summary
In any cell type, less than 10000 are expressed. The human genome encodes about 21000 protein encoding genes. Genes are expressed at different levels (high and low) The expression of the correct genes is essential for growth and differentiation. A gene that is expressed a lot in the human brain is hardly expressed in the human liver. Both tissues contain the gene but they contain different levels of transcription/translation. Most diseases are due to altered expression of one or more genes. By therapeutically manipulating gene expression, we have the potential to prevent or reverse disease. Genetic information flows from dna to rna to protein. Steps at which gene expression can be regulated in a eukaryotic cell. Transcription: initiation, elongation (speed of polymerase, termination (polymerase must fall off) Rna processing (pre-mrna-mrna: rna editing, 5" capping, splicing, 3" polyadenylation. Mrna export from the nucleus to the cytoplasm.
