Biochemistry 2280A Lecture Notes - Lecture 4: Aspartic Acid, Amine, Hydrogen Bond

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Derek Mc Lachlin

Document Summary

Biochemistry lecture 4/5 september 17 & 19, 2018. Example problem: what is the net charge of the alpha-amino group at ph 11? pk ac. = 10 an: 0, +0. 1, +0. 5, +0. 9, +1, net charge of amino acids. To find overall net charge, you need to add up net charge of all ionizable groups at a given ph. Examle problem: aspartic acid at ph 7. Topic 3 protein structure: peptides and proteins. Proteins are linear polymers of amino acids. All proteins are polypeptides, but not all polypeptides are proteins: the peptide bond. The product of a condensation reaction (water is released when two amino acids join) Notice that when a peptide chain forms, the middle charges disappear and only the terminals contain charges this shows that a polypeptide is directional (not symmetrical) The backbone of a peptide is always the same.