Biochemistry 2280A Lecture Notes - Ketone Bodies, Ketone, Adipocyte

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16 acetyl-coa part 2: fatty acids, ketone bodies, and biosynthesis. Low glucose conditions: breaks down triaglycerols in adipocyte; lipase will break the fatty acids off glycerol. Fatty acids go to liver and muscle, not brain: glycerol foes to liver. Fatty acyl-coa is transported into the mitochondrial matrix; driven by the hydrolysis of atp. Fatty acid goes through a series of 4 cheimcal reactions each set of reactions get an acetyl-coa, and. Nadh, and fadh2 and an acyl-coa that is 2 carbons shorter. Acyl-coa + n-1 fad + n-1 nad+ + n-1 coa n acetyl co-a (enters cac or in liver made ketone bodies) + (n-1. Each fadh2 gives electrons to q to make qh2, but using different protein complexes. Oxidation of fatty acids: special cases: oxidation of unsaturated fatty acids yields fewer fadh2 and may consume. Nadph: oxidation of odd chain fatty acids yields one propinyl-coa, which enter the cac as succinyl-coa.

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