Biochemistry 2280A Lecture 18: McLachlin Notes 18-22

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Mclachlin topic 18 lecture notes: introduction to dna and rna. Explain the chemical structure of nucleic acid polymers, without memorizing structures of the nitrogenous bases. Describe b-dna and the higher order structures formed by rna, and the important forces that stabilize these structures. Identify chemical and structural similarities and differences between dna and rna. Rna: template for producing proteins (mrna, makes up much of the ribosome (rrna, carries amino acids to ribosome (trna) Ribonucleotides, composed of three parts: a sugar, a nitrogenous base, and a phosphate. Two types of nitrogenous bases purines and pyrimidines: all purines and pyrimidines are planar and hydrophobic. Purines found in dna and rna are adenine and guanine: they join to c1" of ribose or deoxyribose via the n9 position. Phosphates are attached to c5" position of ribose or deoxyribose by a phosphoester linkage. After a phosphate is attached to this position of a nucleoside, a nucleotide is formed.

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