Biochemistry 3381A Lecture Notes - Lecture 9: Glycogen Phosphorylase, Filter Paper, Citric Acid Cycle

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Metabolism is the overall process through which living systems acquire and use free energy to carry out biological functions. Various pathways are present within the body, representing various metabolic processes that cross over each other. There are ~4000 reactions, subcategorized into 4 types. Signal transduction is a series of biochemical reactions that produce a biological response (i. e. a metabolic pathway involving a network). There are lots of reactions which are categorized into many types. When metabolism is perturbed, the system is dysregulated ex. B-raf activity is turned on causing melanoma cells to become. Initially, precision medicine proved helpful; however, the cells adapted and the disease reappeared: regulation and integration of metabolism i. Metabolism: overall process for acquiring and using free energy. Catabolism: degradation of nutrients or cell constituents (generate energy) Stage 3: catabolic pathways converge on citric acid cycle to yield simple end products. Anabolism: biosynthesis of biomolecules from simpler components (requires energy)

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