Biochemistry 3385A Lecture 3: Lecture 3 Apoptosis
4 Feb 2015
School
Department
Course
Professor
Document Summary
Essential cell biology third edition - bruce alberts, dennis bray, karen hopkin, alexander johnson, Julian lewis, martin raff, keith roberts, peter walter. The biology of cancer second edition - robert weinberg. Objectives: define the characteristics of apoptosis, explain how caspases are activated, define the different proteins that participate in the apoptotic pathways. Extrinsic pathway: describe how apoptotic proteins are regulated, explain how apoptosis is deregulated in cancer. Apoptosis is also activated by: cellular stress, lack of nutrients, growth signals or oxygen, dna damage, damage, or malfunction of organelles or alteration of cellular metabolic processes (including, but not restricted to: er stress, excessive internal. Ca+ concentrations, oxydative agents, inhibition of protein synthesis / protein degradation: signals from the immune system. Apoptosis is often inhibited in cancer cells which allows them to survive despite the internal stress signals and deregulated metabolism that occurs in these cells. Traumatic cell death with leakage of intracellular contents.
