Biology 1001A Lecture Notes - List Of Epidemics, Integrase, Reverse Transcriptase

• School: Western University
• Department: Biology
• Course: Biology 1001A
• Professor: Tom Haffie

Document Summary

Optional readings russell et al p 491-493 (2nd ed) Tree of life: where do viruses fit? replication. Hiv lifecycle: hijack immune cells: virion (viral particle) enters host cell, reverse transcriptase. Dna into host dna: transcription, translation, new virions assemble and bud off or lyse out. Evolution of drug resistance: mutations produce virions that vary in drug resistance, resistance passed from parents" to. Offspring": not all virions reproduce, in the presence of the drug, resistant forms are more likely to reproduce than susceptible forms, viral population changes over time (by evolution natural selection) Evolution by natural selection: mutations produce virions that vary in drug resistance, resistance passed from parents" to. Offspring": not all virions reproduce, in the presence of the drug, resistant forms are more likely to reproduce than susceptible forms, viral population changes over time. Resistance to one drug is inevitable: to many drugs is less likely.