Biology 1001A Lecture Notes - Lecture 10: Envelope Glycoprotein Gp120, Gp41, Integrase

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30 years ago, hiv was beginning to be diagnosed 1981. Pandemic epidemic happening around the world. Estimated # of deaths 90 million by 2020. Spanish flu 50 to 100 million. Large fraction of hiv patients in afria are aminly women and children. Precipitous drop in the average life expectancy in african countries in 1980s when hiv began to spread. So aren"t part of the tree of life. Don"t have their own metabolic process not cellular (cell based) Virion can"t replicate except inside a host cell. A lipid coat, a few protein receptor, inside genetic info, very few genes on average compared to us. Obligate intracellular parasites they can"t replicate themselves except when their inside an infected host cell. They hijack the hosts cellular machinar host own enzymes, energy source, metabolism and uses that to replicate themselves. Very difficult to treat and make anti-viral drugs. Uses same mechanism as the host cell so have to attact the host cell.

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