Biology 1001A Lecture Notes - Heritability, Drug Resistance, Thymidine
9 Nov 2012
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Lecture 2:- evolution in action: human immunodeficiency virus (hiv) p 491-493. Number of people& children living with hiv increased. Azt mimics thymidine and inhibits reverse transcriptase but eventually stops working because of azt resistance. Evolution of drug resistance: mutations produce virions that vary in drug resistance resistance passed from parents" to offspring" not all virions reproduce in the presence of the drug, resistant forms are more likely to reproduce than susceptible forms. Resistance to one drug is inevitable: to many drugs is less likely. Selection pressure imposed by hiv (plague, small pox) Selectively favoured in north europe during historical epidemics. Summary: evolution in action: evolution can be very fast, even non-living things can evolve. Hiv evolution involves themes such as: mutation and variation, natural selection, evolutionary history, humans as an evolutionary force & as the products of evoltuion. Lec 2 hiv: the general mechanisms by which vaccines protect against diseases. Attaches to the cells of bacteria and detach it.
