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Lecture 13

Lecture 13 Prokaryotic Gene Regulation.docx

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Biology 1002B
Tom Haffie

Lecture 13: Prokaryotic Gene Regulation Monday, March 04, 2013 3:50 PM Today's Topics:  Diverse types of signals in DNA  The role of complementary base pairing  Differences b/w euks and proks  The role of RNA Announcements:  Homework: Lecture Topic:  Modern endosymbionts have a "prok" genetic system  In contrast to the nuc which is euk in nature  A typical prok gene ahs many types of signals coded in DNA  Left to right: Promoter SD Box Start codon GENE Stop codon Termination sequence  What if there is a mutation in the promoter  The efficiency of the promoter could be positive or negative  The promoter could become more/less attractive to RNA pol  What if there is a mutation in the SD Box?  Unless the mutation creates a start codon, it might make the SD Box more or less attractive to rRNA  What if there is a mutation in the start codon?  Pretty much all you can do to a start codon is break it,  Kills the gene  No transcription  What if there is a mutation in the coding region  There are redundancies  Trp: UGG  Because of redundancies, when a mutation happens, the effects of mutation depends on where and how the mutation affects the codon  Silent mutation: sub one codon for another but code for the same aa  Missense codons: sub one codon for another and another aa  Nonsense codons: creating stop codons  Indel mutation: cause a shift in reading frame  What sets the reading frame?  Sta
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