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Lecture 17

Biology 1002B Lecture 17: Lecture 17

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Department
Biology
Course
Biology 1002B
Professor
Denis Maxwell
Semester
Winter

Description
Lecture 17 Wednesday, March 15, 2017 4:42 PM Synthesis of all proteins being on cytosolic ribosomes… • The synthesis of all proteins that are coded in the nucleus, begin their translation on free cytosolic ribosomes • Every mRNA that comes out of the nucleus begins translation on free ribosomes in the cytoplasm Organelle proteins are targeted for post-translational import via channels • Some proteins need to end up in the chloroplast • The genes for these proteins used to be in the chloroplast but they have been moved to the nucleus So now these proteins are produced in the cytoplasm and need to be ○ imported and they are sorted as a result of tags • The tag is a part of the protein and is recognized by transport proteins that enable that protein to be imported Nuclear proteins are targeted for post - translational import through pores • Some proteins have to function in the nucleus so they need a nuclear tag • The tag that was on the chloroplast protein got removed as the protein was imported into the chloroplast • Proteins that are imported into the nucleus keep their tag • Some proteins have to function in the nucleus so they need a nuclear tag • The tag that was on the chloroplast protein got removed as the protein was imported into the chloroplast • Proteins that are imported into the nucleus keep their tag ○ During repeated cell divisions the nuclear membrane breaks down and the proteins would have to be released and then they would have to be re-imported ○ Nuclear proteins always need to be -rmported but organelle proteins only need to go in once Endomembrane proteins are targeted for co-translational import into the ER • Three destinations that proteins may need to go ○ Stay in the cytoplasm ○ Go into an organelle which is why they are tagged ○ They end up on
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