Biology 1002B Lecture Notes - Lecture 17: Pupa, P53, Ubiquitin
15 Apr 2013
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Volvocine algae provide a productive model system: from last class find time to look at lecture 16. Division of mortality : some cells need to die, some cell"s dna will not make it to the next generation. Maybe its damaged, or got infected by virus, dying on purpose. Programmed cell death mechanism: executioner caspases are proteases that cleave essential proteins, leading to a controlled, but irreversible, biochemical cascade causing cell shrinkage, chromatin fragmentation and cell death, most cells use this, no signal. Active ced-9 protein inhibits activity of ced-4 protein. Repressors, proteins can bind on to other proteins to shut them down. Maybe you can cut them: death signal. It can also start from the inside, doesn"t have to be signal from outside. In silico methods have identified caspase orthologous in bacteria How to inactivate proteins: (post translational to regulate protein: methylate them, change shape, (environment, cofactor, binding on to another protein.
