Class Notes (839,092)
Canada (511,185)
Biology (6,826)
Biology 1002B (1,346)
Tom Haffie (863)
Lecture 17

Lecture 17: "Cancer"

3 Pages
75 Views

Department
Biology
Course Code
Biology 1002B
Professor
Tom Haffie

This preview shows page 1. Sign up to view the full 3 pages of the document.
Description
Biology Lecture No 17 Cancer thMonday March 12 2012 RECALLThe methylation of cytosine is one common mechanism of epigenetics The direct modification of histones with the acetylation or methylation of histone tails is another mechanism by which this can occur Chromatin remodeling is also an example of epigenetic regulation When vertebrate females inactivate X chromosomes a mosaic between paternal and maternal Xchromosomes is observed When making gametes you put sexspecific methylation tags on your DNA The SD box and the terminator sequence in prokaryotes are examples of sequences that are transcribed but not translated Enhancers and ER target sequences do not fall into this category as enhancers are not even transcribed and ER target sequences are both transcribed and translated Entire XChromosome Inactivation How is it possible to inactivate an entire chromosome in X inactivation There are two likely explanations One notion is that chromatin which is loose and available will become more likely to be transcribed In the chromosome with less available chromatin it is typically inactivated almost entirely The other likely scenario is that the chromatin is shut down by an RNA gene on the X chromosome called XIST XInactive Specific Transcript XIST is produced only from the inactive Xchromosome it still functions as RNA but when it associates with the Xchromosome its binding all over it eventually suppresses the chromosome
More Less
Unlock Document

Only page 1 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit