Class Notes (809,271)
Canada (493,607)
Biology (6,677)
Biology 1002B (1,340)
Tom Haffie (863)

Biology Lecture 21 Outcomes

2 Pages
Unlock Document

Western University
Biology 1002B
Tom Haffie

Lecture 21 Most radiation exposure is “natural” ROS can cause breaks in DNA helix, resulting in rearrangement  You can detect a broken chromosome  Results in deletions etc  Inversions  Translocations  Result from cells attempt to repair double stranded breaks in chromosomes Burkitt Lymphoma: fusion of oncogene and strong promoter  Translocation: piece of 8 swapped for 14  8: Myc is an oncogene  14: has antibody producing ssequences  Swap causes Myc to swap with antibody genes  This causes lymphoma Blood and lymph cells all arise from hematopoietic stem cells in bone marrow  All come from hematopoetic stem cells  Maturation of B cell is where antibodies etc happen  Innate immunity  Share with other organisms such as plants, etc  Nonspecific, goes after everything  Consumes bacteria via phagocytosis  Cytokines and chemokine are chemical messenger protiens used to communicate with other cells to attract them to the site Adaptive Immunity is more specific and has a memory  Cell based o Cells that are doing the killing o Lysosomes and proteasomes break stuff up o The bits of broken virus are advertised on cell surface o T cell has a receptor that matches to that virus and sends signal to replicate o T cells go and find other viruses o Use Per o forins: puncture holes in infected cells o KILLER Ts  Antibody based o HELPER Ts o Dendritic Cell, again engulf a bacteria, break it down and display the antigens on its surface o Shows them to T4 cells to see which one recognizes it o Each t cell has a different receptor o T cells release interlukens to stimulate the particular T cell to divide o The T cells now go looking for a B cell o Help B cells respond to same threat
More Less

Related notes for Biology 1002B

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.