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Biology 1002 Connecting more concepts to energy transformation.pdf

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Department
Biology
Course
Biology 1002B
Professor
Tom Haffie
Semester
Fall

Description
Lecture 7:Energy Transformation 2 • Cellular respiration • catabolic...exergonic • lots of C-H bonds in carbs,fats, proteins • take energy from food and create ATP Where is it found? What does it do? Free energy? (lots of free energy in glucose) Requires O2? Where is the carbon? Compare with photosynthesis Lecture 7:Energy Transformation 2 Glycolysis: splitting of glucose • dont need specialized membrane just need enzymes • most organisms have it • nothing particularly eukaryoktic about this • produce of glycolysis is 2 pyruvate molecules 2 ATP consumed • What has more free energy glucose or 2 pyruvate? • glucose Lecture 7:Energy Transformation 2 Half reactions ATP + H 2 ADP + Pi ΔG= -7.3 kcal/mol Pi + glucose glucose-6-P ΔG = + 3.3 kJ/mol Coupled reaction: ATP + glucose ADP + glucose-6-P ΔG = -4 kcal/mol Lecture 7:Energy Transformation 2 • overall reaction is exergonic • ATP stable • if ATP was very fast the cells would just heat up • kinetically it is not a fast reaction • a water molecule cannot get into the active site • the enzyme breaks away the phosphate and transfers it to the glucose • no real ATP hydrolysis occurring when you phosphaorlate the glucose it has a higher free energy • • phosphate is negative glucose is postive, its to keep it in the cell Substrate-level Phosphorylation • molecules that want to give away phosphate are said to have high phosphoryl transfer potential, glucose is an example Lecture 7:Energy Transformation 2 Mitochondria Outer mitochon Inner mitochon Ma Intermem Linking Glycolysis and Citric acid Cycle Cytosol Mitochondrial matrix Pyruvate ▯ ▯ ▯ ▯ ▯ ▯ Acetyl CoA • Pyruvate dehydrogenase complex Decarboxylation: get rid of CO2, no free energy • CO2 in gray cir
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