Biology 1002B Lecture Notes - Lecture 7: Pyruvate Dehydrogenase Kinase, Pyruvate Dehydrogenase Complex, Acetyl-Coa

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Cellular respiration is converting free energy in ch bonds into atp. Potential energy in food has lots of ch bonds, is conserve energy by changing to a form that cells can use (atp). Cellular respiration (what we should know for exam): Splitting of glucose, beginning of cellular respiration. Cytosolic pathway, don"t need specialized membrane, just need enzymes floating around in cytosol. Only the location is different in eukaryotes as opposed to in bacteria for example. Two molecules of pyruvate is the product of glycolysis, extract energy from glucose to reduce nad to nadh (oxidation). Initial consumption of atp (energy investment stage) and then get two atp out and two nadh from one glucose molecule. Energy coupling: first reaction, glucose and hexokinase come together with phosphate, gives positive delta g, endergonic. Hydrolysis of atp is the exergonic reaction in energy coupling. Energy coupling happens all over metabolic pathways. Kinetically it"s not a very fast reaction although it"s very spontaneous.

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