Biology 1202B Lecture Notes - Lecture 12: Semiconservative Replication, Phosphodiester Bond, Polynucleotide
19 Apr 2013
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Watson and crick won nobel prize for discovery. Franklin played role because she helped discover it through x-ray diffraction died because of things she worked with and her notes ended up with watson. X- shaped pattern of spots was correctly interpreted by franklin to indicate that. Dna has a helical structure similar to spiral staircase. Dna contains nucleotides joined to form a polynucleotide chain. In a polynucleotide chain, the deoxyribose sugars are linked by phosphate groups in an alternating sugar-phosphate-sugar-phosphate pattern, forming a sugar- phosphate backbone. Each phosphate group is a bridge between the 3" carbon of one sugar and the. 5" carbon on the next sugar; the entire linkage, including the bridging phosphate group is called a phosphodiester bond. At one end, a phosphate group is bound to the 5" carbon of a deoxyribose sugar (5" end), whereas at the other end, a hydroxyl group is bonded to the 3" carbon of a deoxyribose sugar (3" end)
