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Biology 1202B Lecture Notes - Nucleoid, Interphase, Semiconservative Replication

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ochrebee715
30 Apr 2012
School
Western University
Department
Biology
Course
Biology 1202B
Professor
Gardiner/ Murphy

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Document Summary

1952 hershey and chase used to believe protein was inherited, but realized it was dna. 1953 watson, crick and franklin discovered the double helix structure of dna: rosalind franklin used x-ray diffraction on a dna sample, which revealed positions of the atoms in the crystal (resembled the helical structure) 1956 tijo and levan discovered there were 46 chromosomes in the nucleus. 1963 margit and sylvan nass discovered mtdna (mitochondrial dna) Nucleotides are the building blocks of nucleic acid (dna and rna: consist of a phosphate group, a pentose sugar and a nitrogenous base. Deoxyribose sugar the pentose sugar in dna, which is missing an oxygen atom. Ribose sugar the pentose sugar in rna, which has the oxygen atom. Nitrogenous bases: guanine (g, adenine (a, thymine (t) not in rna, uracil (u) not in dna, cytosine (c) Dna and rna are made up of dntp (deoxynucleoside triphosphate: examples: datp, dctp, dgtp, dttp, and dutp. Differences between rna and dna: ribose sugar.

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Related Questions

1a. Who was the author of the 1968 book titled “The Double Helix”?

1b. Why was this book so controversial?

1c. What technique was Rosalind Franklin first introduced to in 1938 at Cambridge University?

1d. After completing her degree at Cambridge, to what country did Franklin move to continue her research studies?

1e. Why was Franklin required to stay away from her lab for several weeks?

1f. What research insti tution in England did Franklin move to after completing her work in France?

1g. What research institution in England did Watson and Crick work at?

1h. What was the first major discovery Franklin made about DNA?

1i. What methodology did Watson and Crick use to determine the structure of DNA?

1j. What specific information, other than the helical nature of DNA, did Watson and Crick obtain from the famous “Photo 51”?

1k. Why was it essential that Franklin's paper be published at the same time as Watson and Crick's paper?

1l. From 1953 to 1958, what was the focus of Rosalind Franklin's research?

1m. Which form of DNA discovered by Rosalind Franklin is wetter and found in cells?

1n. True or False: At one point, Watson and Crick were forbidden to continue on with their DNA structure research because of their technical errors.

1o. How many strands of DNA did Rosalind Franklin have to bundle together for her experimental work?

1p. What information about DNA was immediately apparent (to Watson, Crick, and other scientists) when they saw photo 51?

1q. Approximately how many hours did it take to expose one of Franklin's DNA photos?

1r. Without computers, approximately how long could it take to perform the calculations necessary to analyze on of Franklin's photographs?

1s. What two published conclusions (later shown to be incorrect) did Pauling make about DNA structure?

1t. In what year was Watson and Cricks DNA paper published?

1u.How old was Rosalind Franklin when she died?

1v. What disease was responsible for Franklin's death?

1w. What did Franklin regard as her “greatest scientific discovery”?

  1. (a) Describe Chargaff’s contribution to DNA structure.(b) Explain why the discovery of Watson and Crick would not havebeen possible without the work of previous biologists RosalindFranklin and Erwin Chargaff.

Q1. Discovering the Structure of DNA. Jim Watson andFrancis Crick were able to build the correct model of DNA based onfour key pieces of information that they learned from the work ofRosalind Franklin, Erwin Chargaff and others. List thefour key pieces of information that led to the correct model. Writeon back of page if you need to. (this is for genetics)