Biology 1202B Lecture Notes - Chemotherapy, Mesenchymal Stem Cell, Public Bank

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Mesoderm = muscle, bone & blood: there must be some kind of internal repair system in stem cells. Example: can remove a huge chunk of your liver and it grows back very quickly. In vitro fertilization has a low success rate, so they typically put 2-3 fertilized eggs back into the mother: the leftovers that would have been discarded as waste are donated to this research, development of the fetus: Fluid enters the morula (big group of cells) and pushes the cells to the outside. The inner cell mass forms the fetus (it is pluripotent) These inner mass cells are the ones that are being researched: removing inner cell mass cells, destroys the zygote/fetus/embryo. Stem cell lines can grow & subculture for many months. After 40-50 divisions, normal cells typically die (telomerase) But stem cells can stay alive for much longer periods of time. Presence of transcription factors & cell surface antigens.

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