Biology 2382B Lecture Notes - Lecture 4: Cell Adhesion, Peptide, Cytosol

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Er: structure and function: protein-targeting, contranslational translocation, protein modifications in er, mitochondrial import of proteins. Recommended readings (8th ed. : chapter 13: p. 584-590, 602-605, 610-611. Must be localized correctly: newly made peptides must be directed to the correct destination to function properly. Direct proteins to the desired destinations (organelles) intracellularly. Direct proteins to the secretory pathway (er, golgi, lysosomes) extracellularly. General principles of protein synthesis, targeting and sorting: many proteins are synthesized just by cytosolic ribosomes: Those which are targeted to intracellular organelles such as (er), mitochondria, chloroplasts, peroxisomes, and nucleus (they have a specific signal sequence: other proteins are synthesized by ribosomes attached to rough er: Those which reside in er and proteins which are sorted to pm, golgi complex, and lysosomes: accordingly, two major protein-sorting pathways are known: nonsecretory and secretory. Basic mechanisms of protein targeting to the membranes of organells are common: receptor for the signal sequence.

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