Biology 2382B Lecture Notes - Lecture 12: Axoneme, Dynein, Basal Body
13 Mar 2017
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Axonemal dynein head bound to a tubule, reaches towards b. The entire axonemal structure is in the cilia and flagella. There"s a relationship between triplets in basal bodies and doublets in the axoneme: where as centrioles don"t, made of triplet mt, directly polymerize the axoneme structure. Nexin connects the ab tubules: nexin is a ladder structure, and found in certain places only. Axonemal dynein is also found in certain places only. The doublet mt inside the axoneme: a tubule has 13 protofilament, b tubule has 10. A tubule will have mt permanently bound to the stem of axonemal dynein. The heads reach towards b tubule of adjacent tubule. Occasionally nexin comes and holds the tubules together. If nexin is removed (theoretically) by protease the dynein heads will try to get to the end (cid:498)regional/localized bending(cid:499) nexin links at one point but sliding still occur. Sliding prevented by nexin but motors are still working so bending created.
