Biology 2382B Lecture Notes - Lecture 13: Myosin, Kinesin, Formins
14 Mar 2017
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Chromosome need to be captured from both sides for proper alignment. Mt needs to feel tension from other side at kinetochore or else it will let go. It will sense tension when the other side is also being pulled. Results in weak mt interactino with kinetochore (lets go) When mt lets go, it tries to attach again until tension from both sides created. Cell somehow knows all 23 pairs of chromomsomes are captured. Process ensures chromomsomes arent near metaphase plate during cytokenesis. In vitro: to show what happens to mt. As anaphase a occurs + end is depolarizing (there is depolarization at end. very insignificant and only happens in pole mtoc) Anaphase b: kinesin 5 will push poles apart and dynein pulls towards plasma membrane. Actin filaments: also called microfilaments, cortical- outside layer, found just underneath plasma membrane, responds to extracellular signals, actin cytoskeleton changes in response to outside signals. Beta actin: in cells under the plasma membrane (most cells)
