Biology 2382B Lecture Notes - Lecture 18: Phospholipid, Amphiphile, White Blood Cell
24 Mar 2017
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Adhesive proteins: laminin, nidogen/entactin, fibronectin: allow cells to migrate/stick. Cell needs to sense ecm to bind to it: Integrin allows sensing ecm: heterodimer, alpha integrin (20 types, beta integrin subunit (10 types) a1b1 - collagen a5b1 - fibronectin a6b1 - laminin, different combinations that recognize different aspects of ecm. For a cell to stick to ecm, needs proper integrin. Ecm proteins (and other proteins) have rgd amino acids (3 separate ones) Integrins bind to a core rgd sequence found in proteins. Synergy region/sequence found around rgd sequence, allow specificity. Somewhere has rgd sequence: a5b1 will come to recognize the rgd core sequence but also recognize synergy sequence specific for fibronectin. Integrins bind a bunch of the sequence that has to have rgd with in (for the course it binds the rgd only) Integrins are transmembrane proteins: cytoplasmic, extracellular, transmembrane domain, cytoplasmic domain of integrin binds cytoskeleton, extracellular domain can bind ecm, ex.
