Biology 2382B Lecture Notes - Lecture 17: Intermembrane Space, Tumor Necrosis Factor Alpha, Fas Ligand

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If no programmed cell death = can have webs: there must be death of interdigit cells, progressive cell death that leads to the formation of digits. Interdigitizations: interfering with mechanisms that trigger programmed cell death during development. Interfere with pro-apoptotic signaling pathways that normally trigger progressive destruction of cells in between the feet = webbing. Programmed cell death (apoptosis) is a key process: ensures normal embryonic development, proper tissue homeostasis in adult animals. Active cellular process that is morphologically distinct from necrosis (where cells swell and burst) Apoptosis: cell dies but it can die in many different ways: put a cell in water, causes osmotic shock (cell swells and blows up, x rays, chemicals. Necrosis: external stresser: through physical and chemical ways that kills the cell, bad thing because everything bursts and it can trigger immune responses. Programmed cell death is controlled: want the cell to collapse in on itself rather than explode everywhere.

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