Biology 2382B Lecture Notes - Lecture 5: Membrane Transport Protein, Cystic Fibrosis, Copii
Document Summary
Long path to get from protein just entering the er until eventually its secreted from the cell. Lots of vesicles moving backwards using retrograde mechanism, but the vesicle movement forward only happens from the er lumen into the golgi network initially, not after. Physical movement of the structures up it changes the function of the proteins inside. The above is not a focous of the course though, focus on retrograde movement (returning things back to er) and formation. Consists of flattened, disklike, cisternae with no ribosomes: has a cis face (which faces the rer) - has medial section and then trans face which is opposite of rer which sandwhiches this. Vesicles at cisterna tip fuse or pinch off. No ribosomes on them it"s smooth! Three tpes of cisternae (cis, medial and trans) and two flanked networks of tubules: cgn faces rer and tgn is opposite to rer. Important for processing and sorting of proteins (particularly secreted, membrane, lysosomal proteins)