Biology 2382B Lecture Notes - Lecture 4: Secretion, Protein Targeting, Cisterna

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4 isolation and analysis of cell organelles and molecules. Learning objectives: protein-targetting, er: structure and function, contranslational, protein modifications in er, mitochondrial import of proteins. Protein sorting/targeting: typical mammalian cell, 10,000 proteins, must be localized correctly, newly made peptides must be directed to the correct destination, targeting, direct proteins to the right destinations (organelles) during or after synthesis. Sorting: direct proteins to the secretory pathway (er, golgi, lysosomes). General principles of protein synthesis, targeting and sorting: many proteins are synthesized just by cytosolic ribosomes, those which remain in the cytosol. Those which are targeted to intracellular organelles such as (er), mitochondria, chloroplasts, , and nucleus (they have a specific signal peroxisomes sequence: other proteins are synthesized by ribosomes attached to er (the rough. Er: those which reside in er and proteins which are sorted to pm, Golgi complex, and lysosomes: accordingly, two major protein sorting pathways are known, nonsecretory secretory.

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