Biology 2382B Lecture Notes - Lecture 9: Transfection, Hydrolysis, Cell Membrane
Document Summary
Basic principles of cell signaling and gpcr system. Some of the players conversion of 1 signal into another. Kinases ( rtk "s ) involves growth factors cytokines , hormones. G - protein coupled receptors ( gpcr "s) neurotransmitters light , sound , etc . Proto . oncogenes ( ras ) controls all aspects of normal development. Protein kinases ( mapk ) and physiology initiator of diseases cancer heart diabetes. Signaling: signal or signaling molecule ( ligand , primary messenger ) small molecules ( epinephrine , acetylcholine , steroids peptide hormones monoamines etc large molecules. , growth factors cytokines ( proteins : receptors. Intracellular signaling and effect or proteins a proteins , protein kinases and phosphatase etc. used for internal processing and elicits cell change. Soluble hormones bind to intracellular receptors which constitute the nuclear receptor superfamily of transcription factors. Steroid hormones are hydrophobic ( many rings ) and are derived from cholesterol.