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Lecture 12

Cell Bio Lecture 12.docx

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Department
Biology
Course
Biology 2382B
Professor
Robert Cumming
Semester
Fall

Description
Apoptosis DNA Damage -ReLoss of Signal Extrinsic Apoptosis Pathway -Triggers recruitment and activation of -Trophic factor; survival factor tells cell -Cell with Fas receptors binds to ligands the kinase ATM to survive on other cell -ATM Phosphorylates P53 -Bind to receptor and triggers Kinase -Recruit together to form trimeric -P53 now stabilized and promotes pathway; phosphorylation of Bad and complex transcription of Puma (BH3 only recognized by inhibitor 14-3-3 -Promotes FADD; causes recruitment of Domains) -No trophic factor, Bad not procaspase 8 which binds FADD to -Puma binds Bcl2 allowing formation of phosphorylated and is active dimerize; initiates procaspase 8 Pore (On Mitochondrial Membrane) -Bad binds Bcl2 and Pore is formed -Goes and activates other caspases; -Pore is formed by Bac and Bax -Cytochrome C is released cleaves Bid -Cytochrome C is released
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