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Lecture 7

Cell Bio Lecture 7,8.docx

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Department
Biology
Course
Biology 2382B
Professor
Robert Cumming
Semester
Fall

Description
The Budding Yeast Cell Human CDK can Mitosis Promoting Factor (MPF) -cdc28 be introduced into -Heterodimer of cdc2 + cdc13 Cdc28 = temperature sensitive at 37˚yCeast and it will -when active it triggers many processes in -cell cycle inferred by size of the bud complement the mitosis -Long G1 phase deficiency The Fission Yeast Cell -Cdc2 (CDK); constitutively expressed; -cdc2 activity peaks as M begins Cdc2 =stuck in G2 phase (long) -cdc13 (Cyclin); levels increase during cell Cyclin Dependent Kinase (CDK) + cycle and peak at M creating heterodimer. -cdc28, cdc2 Cdc2 =enters mitosis earlier (short) (Not constitutively expressed) -Longer G2 and M phase Wee1 -Mammals; G1/S, S, M (cdc2) -Kinase; inactively phosphorylates cdc2 in Cyclin S/G2 phase -G1, G1/S, S, M (cdc13) Cdc25 -heterodimeric partners with CDKs, -Phosphatases; actively removes phosphate regulate activity -Interact with kinases late G2 Phase
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