Biology 2382B Lecture Notes - Lecture 10: Glycogen Synthase, Cgmp-Dependent Protein Kinase, Phosphatase
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Depending on the ligand-receptor complex; either an activator or inhibitory g will be turned on. G subunit activates the effector protein (k+ Activate g-protein; causes active g subunit to dissociate. Binds to g subunit and keeps it in. Keeps cl- channels open (cftr) leading cl- out of cell and water goes with it. Coupled (pka) by camp camp regulates protein kinase a. Camp binds to b site then a site of. Promotes dissociation of regulatory domain from catalytic subunits and they can go phosphorylate things. Active pka; phosphorylates to ultimately convert glycogen to g1p. Phosphatase dephosphorylates making glycogen synthase active and inhibiting glycogen breakdown. Genes regulated by pka contain a specific nucleotide sequence (tgacgtca) called the camp. Catalytic domains of pka enter nucleus and phosphorylates creb. Binds to g i and keeps this inhibitor in. A stimulation of acetylcholine gpcr on endothelial cells incduces an increase in.