Biology 2382B Lecture Notes - Lecture 11: Alpha Helix, Gtpase, Proline

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Trigger ligands of growth factors/insulin: single alpha helical conformation intrinsic tyrosine kinase stimulated by ligand bind due to dimerization require adaptor proteins. Pathway require 2 rtk associated together following ligand binding with kinase domain in cytosol. When activated phos directly or recruit protein to trigger ras. Activation of rtks: rtk extracellular bind to ligand, rtk intracellular has intrinsic tyrosine kinase activity, when ligand bind cause dimerization triggering activation of cytosolic kinase. Activate rtk part in cytosol and up w/lots of tyrosine residue which acts as a beacon or adaptor proteins eg. sh2. Oncogene: chicken tumours grinded up and injected to healthy chicken which also develop it, virus that transmit cancer. Sequence genome and found some chicken dna in it. Virus integrate piece of genome of host, piece taken was a kinase but left a piece behind that code tyrosine residue that activates kinase activity during phos.

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