Biology 2382B Lecture Notes - Lac Operon, Stb, Repressor
Document Summary
So far, we have examined gene regulation in a strictly qualitative manner (e. g. the transcriptional levels of the lac operon were either high or low; the presence of glucose in the growth media decreased transcription of the lac operon). The goal of quantitating gene regulation is to create working mathematical models of two very simple genetic networks. Here is a model we can use for a given gene y: Using this model, we can quantify the rate of mrna production and degradation for gene y using a source and sink model: The y mrna is being accumulated in box y in nmoles: Sink dy/dt = b - ay degradation rate, accumulation of y mrna in the box. rate < degradation rate, loss of y mrna in the box. production rate = degradation rate, levels of y mrna stay the same.
