Biology 2382B Lecture Notes - Lecture 1: Cdc42, Focal Adhesion, Immunoglobulin Heavy Chain
15 Mar 2015
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Document Summary
Made of (4), & actin. Fh2 binding domain sits on + end and helps polymerize. Rho-gtpase binding domain binds to rho and becomes activated. Regulated by nucleating promoting factor wasp: wasp activated by cdc42. Very short tail binds to plasma membrane. Usually dimer: 2 heavy chains 2 light chains. Heavy chain: head, neck & tail region. Light chain: associate with neck region, binds to cargo, regulate speed longer neck = more light chains = faster. Dimer two heavy chains & light chains. Lots of light chains associated with longer neck region. Muscle contraction: with atp binding, myosin releases off actin but still holds onto adp and phosphate. Myosin can bind to actin in the absence of atp: rigor state. Neuron stimulates muscle cell and action potential is generated over plasma membrane. Deep tubular invaginations of plasma membrane carry nerve impulse across muscle cell.
