Biology 2382B Lecture Notes - Lecture 8: Adenylyl Cyclase, Protein Kinase A, Cgmp-Dependent Protein Kinase
28 Apr 2016
School
Department
Course
Professor
Document Summary
Gpcrs and second messengers are involved in many pathways including glycogen metabolism, development & disease, muscle relaxation, and more. These pathways are exploited by pathogens such as whooping cough and. Cholera, drug companies such as sildenafil, viagra, levitra, etc, and drug dealers such as meth, ecstasy, and more to make the drugs more potent. The general pathway is that there is first a ligand which binds to a receptor protein (7 transmembrane domains). These ligands come in a large variety including light, lipids odor (scents), neurotransmitters, hormones, pheromones, etc: once activated, the receptor will activate the g-signal transducing protein. This protein has 3 subunits: the alpha, beta, and gamma. The alpha and gamma subunits have lipid tails which allow them to associate with the plasma membrane. When a ligand-activated to the alpha subunit, the gdp leaves and a gtp enters which causes the alpha subunit to dissociate from the beta and gamma subunits of g protein.
