Biology 2382B Lecture Notes - Lecture 14: Focal Adhesion, Leukocyte Extravasation, Oligosaccharide
23 Aug 2016
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Keratin is an if found in epithelial cells: helps hold epithelial cells together (provides tissue strength/integrity) Desmin is an if found in muscle cells: supports sarcomeres and links muscle cells together from the inside. Vimentin is an if found in mesenchymal cells (migrating cells e. g. fibroblast) Neurofilaments are ifs found in axons: helps support axon. Lamins are ifs found in all cell types: support nuclear envelope note: cancers deform cells and are not identifiable; presence of ifs can be used to identify what type of cell it came from. Intermediate filament associated proteins only organization proteins identified (no motors, caps, severing proteins) Plectin (green) is an ifap that cross-links if vimentin (blue) to microtubules (red) note: If associated proteins (ifaps) link ifs to other things in the cell (membranes, other cytoskeletal components etc. ) since plectin associates with mts it is also considered a map.
