Biology 2581B Lecture Notes - Lecture 11: T Cell, Ampicillin, Sacrum
20 Feb 2017
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Early on, we relied on mutants which either occurred spontaneously or were induced. Nowadays, we like to generate mutants with a specific mutation (very particular changes) in a specific place (very particular genes) if we can. Often morphological mutants some observable change. 1873 first documented arabidopsis mutant by alexander braun. 1990 this gene was cloned and characterized. Codes for one of many transcription factors involved in the regulation of flower organ development. 1910 discovered by thomas hunt morgan and lilian vaughan morgan. 1st sex-linked mutation ever discovered in the fruit fly. Brachyury mutation: greek brakhus short; oura - tail. Heterozygous: affects tail length and sacral vertebrae. Homozygous: lethal at around embryonic day 10 due to defects in mesoderm formation, notochord differentiation and the absence of structures posterior to the forelimb. 1962 discovered by n. r. grist in glasgow. The genetic basis: disruption of the foxn1 gene: elegans. 1974 first suggestion to use this as a model organism.
