Biology 2581B Lecture Notes - Lecture 16: Human Genome Project, Non-Coding Rna, Methyl Group
Document Summary
Sequenced and annotated all the genes in the human genome. Goal was to uncover all the functional elements in the human genome particular those in non coding parts. They found thousands of new regulatory sites, around 400,000 transcriptional enhancers and 70,000 promoters. 8. 5% of the genome is involved in transcription factor binding. 75% of the human genome is transcribed into rna (transcriptionally active) 80% of the human genome is associated with at least one biochemical function: so about 20% has no observable function. What do you define as function: does biochemical function mean the same thing as being functional, their definition of functional is imprecise. Anything that is transcribed is functional - since transcription is a biochemical function. Things are getting transcribed all the time and it doesn"t appear to do anything. Most of that 75% is transcribed, noncoding rna. Do the regions that are not transcribed have a function: probably noise, just noise.