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Lecture 7

Lecture 7: "Tetrad Analysis"

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Biology 2581B
Jim Karagiannis

Genetics Lecture No 7 Tetrad Analysis thWednesday January 30 2013 Introduction Sequenced genomes are unhelpful when the gene of interest is among 20000 other genes Gene linkage becomes useful as it is the process of finding genes proximal to the gene of interest An example of linkage is demonstrated in males who have haemophilia A that are often colorblind as the traits for this sexlinked mutation are inherited together In contrast individuals with haemophilia B do not necessarily inherited together the responsible genes are far away from each other or on different chromsomes Meiosis In Budding Yeast Saccharomyces cerevisiae bakers yeast is a budding yeast important for studying the consequences of meiosis In this species there are two haploid mating types a andwhich fuse to form a diploid gamete After meiosis is complete the gametes form an ascus a membranous sac containing the spores which germinate to become the two haploid mating types and restart the meiotic cycle These ascus spores can be isolated and cultured in a given medium with the genotype of each individual spore determining its survival in the medium In a rich medium both wild type URA and mutant ura lacks enzyme needed in uracil synthesis pathway spores will grow however in a medium lacking uracil only the wild type will survive It is impossible to know which spores are mutants just by mere observation Examining Two Unlinked Genes On Different Chromosomes In Budding Yeast In budding yeast the unlinked genes HIS4 and TRP1 are wild type alleles
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