Biology 2581B Lecture Notes - Lecture 10: Base Pair, Ferrochelatase, Reverse Transcriptase
27 Feb 2019
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Promoters are position-dependent: can"t move a promoter around much and expect it to continue to function properly, but enhancers are much less position-dependent can move enhancers around a lot. If we invert a promoter, it would no longer drive its normal gene dead: but if we invert an enhancer, it could still work, would form a more complicated loop. Compare & contrast promoters and enhancers: both bind dna proteins, but function differently. Insulators are also protein binding sequences: are powerful gene expression elements. They can restrict the range of influence of enhancers, so that enhancer doesn"t upregulate every gene and only upregulate certain genes. If taa is in the intron, it messes up splicing signal, so intron isn"t spliced, so. Protein is too short so it doesn"t work: non-sense. Creates pre-mature stop codon indirectly: transversion, base substitution, recessive. These are triplet repeat mutations: earlier we looked at how they occur: by a replication slippage, don"t memorize this.
