Biology 2581B Lecture Notes - Lecture 16: Lac Operon, Repressor, Regulatory Sequence
15 Mar 2015
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Document Summary
So far, we have examined gene regulation in a strictly qualitative manner (e. g. the transcriptional levels of the lac operon were either high or low; the presence of glucose in the growth media decreased transcription of the lac operon). The goal of quantitating gene regulation is to create working mathematical models of two very simple genetic networks. Here is a model we can use for a given gene y: Quantify rate of mrna production & degradation for y: Degradation rate depends on the amount of y mrna that is present. If a = 0. 1/min, 10% of y mrna is degraded every minute. If at an instant in time, there are 1000 nmoles, the rate of degradation is 100 nmol/min. If at another instant in time, there are 100 nmoles, the rate of degradation is 10 nmol/min. A = 10 nmoles / min x 100/nmole = 0. 1/min. Transcription of gene can be simulated with computer program.
