Biology 2581B Lecture Notes - Lecture 19: Contig, Bioinformatics, Cytochrome C Oxidase Subunit I

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Bioinformatics is piercing every aspect of daily life lots of jobs in the bioinformatics/genomics sector. Assembling genomes (taking pieces of dna and putting them together into a bigger genome) is one of the most challenging and important parts of bioinformatics o. The data are easy to generate but hard to put together. 1,000s of sequencing centers generating thousands of genomes a minute. 25 nt region that"s identical at either end. Can line them up assuming that in their identical in this region because they come from same dna. Assembled into a contig: 2 sequencing reads overlapped by 25 nt o length of contig = 275 nt. Chance that 1 site is identical = 0. 25. Chance that 2 sites are identical = 0. 25 x 0. 25 = 0. 0625. Chance that 25 sites are identical = 0. 2525 = 0. 000000000000001. Repeat elements that repeat several times in different amounts on different reads: overlap between the 2? o.

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