Class Notes (839,072)
Canada (511,181)
Biology (6,826)

10-Neuralation and Patterning.pdf

12 Pages

Course Code
Biology 3338A
Sashko Damjanovski

This preview shows pages 1,2 and half of page 3. Sign up to view the full 12 pages of the document.
•  Stuff going through dorsal li[pà dorsal mesoderm •  Anterior and posterior neural are different •  All kinds of singalling events •  All cocuring in a gradient •  RAà renpic acid gradient from anterior to posterior •  Gradient tells noggin where it is, allows it to make the right structure •  Dorsal side makes dorsal mesoderm •  3d of mesoderm, but only dorsal emsoderm signals neural •  In frog all dorsal mesoderm is there before neuralations starts; in frog neuraltation doesn’t start until gastrulation finsihes 1 •  Take ectoderme befre its induced, if transplant it will form epidermis •  Cells in dorsal lip. First part that go through dorsal lip is the mst anterior. Take early dorsal lip, will form another axisà mainly anterior •  If take late dorsal lipà get another posterior axis •  Take late dorsal lip ectodermà will form neural (has the proper stuff that induces bmp)? 2 •  No need to memorize anything here •  Bmp makes etoderm epidermis •  On the flip side, if inhibit bmpà will form neural tube and brain and associated structures •  In between the twoà get neural crest (after mid term stuff) 3 •  Dorsal mesoderm is specialà forms the notochord. Notochord signals to form neural tissues •  Dorsal side of embyo looks different because eof this •  Dorsal mesoderm leads to primary neuratlation pf 98% •  Three steps plate formation, groove formation, tube formation •  First fromation of plate: •  Dorsal mesoderm broad to start •  Gastrulation causes dorsal emsoderm to separate and form a tube (convergence extension).At same time secreding noggin, and inibihitng bmps •  Ectoderm changes shape, and mesoderm is starting to segment •  First thing is nortal chord; everything makes dorsal comes from nortochords •  If ur abover nortochord, get a lot of singals and become neural plate. If far away stay epidermis •  Inbetween ur special, form the neural crest •  Neuraltaion occurs in 3 steps: formation of neural plate, froamtion of 4 •  Have plate region off thicker cells •  After fromation of plate get the groove (requrires bending) •  Nortochord singals using sonic hedghog; causes cells above to bend and form a groove •  Calls mhp cels •  Actin mypsin allows for apically constiction that’s neeed •  In chickà posterior marginal zone; as thin run from through node from ant to post; have dorsal mesoderm that wll from neral plate •  Epdidermis closes causing dlhpà hing e pints •  Formed neural plate; bmp is inhibited •  Secind step is formation of the goup •  Occurs due to sonic hdghg singnalling •  Sonuc hdghhg causes cells to apically contrict; fomr s a medial hingepoint •  Hingepoint froms groove 5 •  Eventually get closing of epidermis on top •  Have dorsal mesoderm; signal to overlying ectoderm •  Bmp is inhbitedà allows formation of enural plate •  Nortochord signals with sonci to get plate cells to form hinge piint •  Dorsal lateral hinge points close and bring top parts of tube to close 6 •  In frog, have neura
More Less
Unlock Document

Only pages 1,2 and half of page 3 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.