Class Notes (807,255)
Canada (492,677)
Biology (6,676)

12-Neural Crest Cells.pdf

12 Pages
Unlock Document

Western University
Biology 3338A
Sashko Damjanovski

•  Further away you are from dorsal, form different things •  Neural crest is a transient structureà gives rise to so many things •  Multipotentà gives rise to many different things •  Not dtereming prior to migration •  Neural crst gives rise to many different typs of tissue •  Multiplotertà deprend on groth factor, tells what they differentiate into •  No dtermined •  Pick up determineants ats they travel 1 •  White streak is neural tube •  For neural tube forme, gas needs to occurà pharangeal endo leads the way •  As you get further wawya from neural tube get bmp expression •  Neural crest cells have been expoed to little bmp •  Anterior end s placoldal; very little bmp andw nt (d-off and frzb) •  Neural crest cells determiend by intermeidate wnt and bmp •  To make neural crest need proper conc of bmp and wnt •  Pax3 pkays a rle in the border •  Means that edge where neural crest is defined by pax 3 •  Intermediate level of bmp causes migratory pathway fro neural crest •  One gene int level of bmp turns on is pax 3à partly determeines if neural crest 2 •  Have notochrord singalling to np •  Get mhp •  Get bmp gradient •  To migrate need to break cell cell juntions •  Snail/slug is needed tob reak cadherein junctions •  As neural tube is closing, snail is expressed to break cadherins, to make them go through epitheleal tranempthlal expressin •  Rhogtpases are needed for actin myosin and other cytoskeletal migrtatory •  Increase n cad not going to get migration •  Snailà breaks cel cel junction; rho needed for migration 3 •  Neural cres cells aer arising as neural tube is closing •  Cranial neural crest cells may migrate before closing •  Cranial and cardiac lumped together; trun and vagal and sacral lumped together •  All nc are multiplotent •  Cranial nc are the most miltiplotentà only ones that can give rise to cartiladge •  Trunk nc is a large chunk of body plan; easisest to sudyà mmst logical •  No somitogeneiss in head region, also nc cells migrate before tube closure in head region 4 •  Trunk nc migrate through 2 pathsà ventral; dorsal lateral •  DLà pass through epi and dermyatome; mgrate just beneath epidermis (btw epi and dermya) •  Và migrate thtrougth the somite; through ant half of sclerotome 5 •  Dl route is anywhere over somites; from the head to tail, dl nc migrate away from dorsal towards lateral •  V nc migrate venrtrally; migrate through ant half of sclerotome •  Migration needs ecmà need integrins •  Wherever they are going need fn and ln s they can migrateà found at ant half •  Migration is restriced by
More Less

Related notes for Biology 3338A

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.