Biology 3338A Lecture Notes - Lecture 9: Notochord, Tcf3, Gsk-3

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24 Jan 2015
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The dorsal organizer is unique. It is established early, and while
many other inductive interactions occur, it is indispensible.
Dorsal Organizer
There is shift in cytoplasm
Grey crescent will allow a normal embryo to form
Transplanting organizer, another dorsal axis is made
Dorsal organizer comes from dorsal lip, dorsal mesoderm (notochord)
The cells of the dorsal organizer and notochord will signal out to make other mesoderm
Further from dorsal notochord you get more ventral mesoderm, all in relation to how close to dorsal
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As the cells of the Organizer change (move) through involution,
their inductive properties change
Role of the Organizer Gilbert 241-271
Activin
300 molecules/cell = goosecoid - dorsal
100 molecules/cell = pax - lateral
Low = blood
Epiboly is pushing the blastopore
The first things that go through the dorsal organizer make the head most anterior
Transplant the dorsal lip early you make more anterior tissue, later the dorsal lip will make more posterior tissue
Late embryo, take induced ectoderm and transplant it, will form neural
Early embryo, ectoderm not induced, will remain ectoderm
Leave ectoderm alone it will become epidermis
During gastrulation the ectoderm will become different kinds of mesoderm
Activin, one of first morphogen molecules discovered to induce cell differentiation to mesoderm
Low amounts, blood
High amounts, notochord/ heart cells
At high levels it is turning on different genes
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