Biology 3338A Lecture Notes - Lecture 15: Chordin, Lithium Chloride, Gsk-3
22 Aug 2016
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Document Summary
Licl treatment increases gsc because licl inhibits gsk3 allowing beta-catenin to be active in all cells more gsc in dorsalized embryo. Uv treatment decreases gsc because uv disrupts beta-catenin localization due to mt de- polymerization less gsc in ventralized embryo. Gsc is nuclear thus specific proteins secreted to cause induction to dorsalize nearby cells. Some proteins activated by gsc are nuclear while others are secreted proteins with a lot of redundancy. Having many molecules with same functions ensures dorsal mesoderm formation even if one molecule gets mutation. Listed are secreted proteins turned on by gsc in do cells. "noggin" because too much noggin = bigger head tells us it must be involved in axis formation. Picture shows frog embryos formed when injected with different levels of noggin mrna from lowest to highest going top to bottom. No noggin (top) = ventralized embryo with no dorsal structures. Normal noggin (middle) = normal embryo with dorsal axis.
