Biology 3592A Lecture Notes - Lecture 1: Necrosis, Y Chromosome, Angiogenesis

• School: Western University
• Department: Biology
• Course: Biology 3592A
• Professor: Kathleen Hill

Document Summary

The rise of de novo mutations & mosaicism: clonal mosaicism: arises when a postzygotic mutational event is detectable in subpopulations of cells as an alternative genotype while not present in the germline genome. Was undetectable until recent technological advances: dna damage: lesion or broken bond. The first thing that happens to dna; reversible: mutation: dna damage that"s been replicated & proliferated; irreversible, clonal expansion: proliferation of mutated cells. I. e. immune system gets rid of necrosis from mutation. Works on the molecular, inter/intracellular, & systemic level: penetrance: proportion of individuals carrying a particular allele of a gene that also, driver mutation: oncogenic or mutated tumor suppressors express an associated trait (the phenotype) Very delicate balance if driver mutation is knocked out, Have genes that drive cells to grow, divide and proliferate. Main component that the positive selection is working on passenger/hitchhiker mutation can take over & mutations can become worse: fitness: mutations either increase/decrease fitness of individual.